Voltammetric Behaviour of Rivastigmine Hydrogen Tartrate and its Determination in Capsule Dosage Form
نویسنده
چکیده
AD is a neurodegenerative disorder charaterized by progressive decline of cognitive functions.The significant deficits in presynaptic cholinergic markers observed in brains of AD patients have led to the formulation of the cholinergic hyphotesis of AD. Current approaches to the treatment of cognitive and behavioral symptoms of AD emphasize the use of cholinesterase inhibitors. Rivastigmine (Exelon®), a carbamate type pseudo-irreversible acetylcholinesterase(AChE) inhibitor, may be advantageous in treating AD, as it plays specificity for central AChE over peripheral AChE or butrylcholinesterase1,2. Hacettepe University Journal of the Faculty of Pharmacy Volume 26 / Number 1 / January 2006 / pp. 1-12
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